Publications of Katherine J. Franz

Papers Submitted

  1. Franks, AT; Peng, D; Yang, W; Franz, KJ, "Characterization of a photoswitching chelator with light-modulated geometric, electronic, and metal-binding properties.", Inorganic ChemistryFebruary,, 2014, 53(3), 1397-1405 [doi[abs].

Journal Articles

  1. Wang, Q; Franz, KJ, "The hydrolytic susceptibility of prochelator BSIH in aqueous solutions.", Bioorganic & Medicinal Chemistry LettersSeptember,, 2017, 27(17), 4165-4170 [doi[abs].

  2. Conklin, SE; Bridgman, EC; Su, Q; Riggs-Gelasco, P; Haas, KL; Franz, KJ, "Specific Histidine Residues Confer Histatin Peptides with Copper-Dependent Activity against Candida albicans.", BiochemistryAugust,, 2017, 56(32), 4244-4255 [doi[abs].

  3. Helsel, ME; White, EJ; Razvi, SZA; Alies, B; Franz, KJ, "Chemical and functional properties of metal chelators that mobilize copper to elicit fungal killing of Cryptococcus neoformans.", MetallomicsJanuary,, 2017, 9(1), 69-81 [doi[abs].

  4. Sansee, A; Meksawangwong, S; Chainok, K; Franz, KJ; Gál, M; Pålsson, L-O; Puniyan, W; Traiphol, R; Pal, R; Kielar, F, "Novel aminoalkyl tris-cyclometalated iridium complexes as cellular stains.", Dalton TransactionsNovember,, 2016, 45(43), 17420-17430 [doi[abs].

  5. Wang, Q; Franz, KJ, "Stimulus-Responsive Prochelators for Manipulating Cellular Metals.", Accounts of Chemical ResearchNovember,, 2016, 49(11), 2468-2477 [doi[abs].

  6. Hašková, P; Jansová, H; Bureš, J; Macháček, M; Jirkovská, A; Franz, KJ; Kovaříková, P; Šimůnek, T, "Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury.", TOXICOLOGYSeptember,, 2016, 371, 17-28 [doi[abs].

  7. Jansová, H; Bureš, J; Macháček, M; Hašková, P; Jirkovská, A; Roh, J; Wang, Q; Franz, KJ; Kovaříková, P; Šimůnek, T, "Characterization of cytoprotective and toxic properties of iron chelator SIH, prochelator BSIH and their degradation products.", TOXICOLOGYMarch,, 2016, 350-352, 15-24 [doi[abs].

  8. Pushie, MJ; Shaw, K; Franz, KJ; Shearer, J; Haas, KL, "Model Peptide Studies Reveal a Mixed Histidine-Methionine Cu(I) Binding Site at the N-Terminus of Human Copper Transporter 1.", Inorganic ChemistrySeptember,, 2015, 54(17), 8544-8551 [doi[abs].

  9. Crumbliss, AL; Franz, KJ; Thiele, DJ, "Preface", BioMetalsJune,, 2015, 28(3), 431-431 [doi].

  10. Crumbliss, AL; Franz, KJ; Thiele, DJ, "Preface. Biometals 2014--Proceedings of the 9th International Symposium Biometals 2014 at Duke University, Durham, NC, USA.", BioMetalsJune,, 2015, 28(3), 431 [doi].

  11. Helsel, ME; Franz, KJ, "Pharmacological activity of metal binding agents that alter copper bioavailability.", Dalton TransactionsMay,, 2015, 44(19), 8760-8770 [doi[abs].

  12. Bureš, J; Jansová, H; Stariat, J; Filipský, T; Mladěnka, P; Šimůnek, T; Kučera, R; Klimeš, J; Wang, Q; Franz, KJ; Kovaříková, P, "LC-UV/MS methods for the analysis of prochelator-boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) and its active chelator salicylaldehyde isonicotinoyl hydrazone (SIH).", Journal of Pharmaceutical and Biomedical AnalysisFebruary,, 2015, 105, 55-63 [doi[abs].

  13. Franks, AT; Wang, Q; Franz, KJ, "A multifunctional, light-activated prochelator inhibits UVA-induced oxidative stress", Bioorganic & Medicinal Chemistry Letters, 2015, 25(21), 4843-4847 [doi[abs].

  14. Alies, B; Wiener, JD; Franz, KJ, "A prochelator peptide designed to use heterometallic cooperativity to enhance metal ion affinity", Chemical Science, 2015, 6(6), 3606-3610 [doi].

  15. Safi, R; Nelson, ER; Chitneni, SK; Franz, KJ; George, DJ; Zalutsky, MR; McDonnell, DP, "Copper signaling axis as a target for prostate cancer therapeutics.", Cancer Research, 2014, 74(20), 5819-5831 [repository], [doi[abs].

  16. Franks, AT; Franz, KJ, "A prochelator with a modular masking group featuring hydrogen peroxide activation with concurrent fluorescent reporting.", Chemical CommunicationsOctober,, 2014, 50(77), 11317-11320 [doi[abs].

  17. Jansová, H; Macháček, M; Wang, Q; Hašková, P; Jirkovská, A; Potůčková, E; Kielar, F; Franz, KJ; Simůnek, T, "Comparison of various iron chelators and prochelators as protective agents against cardiomyocyte oxidative injury.", Free Radical Biology & MedicineSeptember,, 2014, 74, 210-221 [doi[abs].

  18. Festa, RA; Helsel, ME; Franz, KJ; Thiele, DJ, "Exploiting innate immune cell activation of a copper-dependent antimicrobial agent during infection.", Chemistry & BiologyAugust,, 2014, 21(8), 977-987 [doi[abs].

  19. Festa, RA; Helsel, ME; Franz, KJ; Thiele, DJ, "Innate immune cell activation of a copper-dependent anti-cryptococcal agent", MycosesMay,, 2014, 57, 56-57.

  20. Folk, DS; Kielar, F; Franz, KJ, "Bioinorganic Neurochemistry"August,, 2013, 3, 207-240 [doi[abs].

  21. Grant, GA; Hankinson, T; Muh, C; Dumont, A, "The 62nd Annual Meeting of the Congress of Neurological Surgeons was held in Chicago, Illinois from October 6-10, 2012. Preface.", NeurosurgeryAugust,, 2013, 60 Suppl 1, v [doi].

  22. Franz, KJ, "Clawing back: broadening the notion of metal chelators in medicine.", Current Opinion in Chemical BiologyApril,, 2013, 17(2), 143-149 [23332666], [doi[abs].

  23. Kumbhar, AA; Franks, AT; Butcher, RJ; Franz, KJ, "Light uncages a copper complex to induce nonapoptotic cell death.", Chemical CommunicationsMarch,, 2013, 49(24), 2460-2462, The Royal Society of Chemistry [23417227], [doi[abs].

  24. Franz, KJ, "Clawing back: Broadening the notion of metal chelators in medicine", Current Opinion in Chemical Biology, 2013, 17(2), 143-149 [doi[abs].

  25. Kielar, F; Wang, Q; Boyle, PD; Franz, KJ, "A boronate prochelator built on a triazole framework for peroxide-triggered tridentate metal binding.", Inorganica Chimica ActaDecember,, 2012, 3930, 294-303 [23439614], [doi[abs].

  26. Folk, DS; Torosian, JC; Hwang, S; McCafferty, DG; Franz, KJ, "Monitoring β-secretase activity in living cells with a membrane-anchored FRET probe.", Angewandte Chemie International EditionOctober,, 2012, 51(43), 10795-10799 [23023944], [doi].

  27. Hyman, LM; Franz, KJ, "Probing oxidative stress: Small molecule fluorescent sensors of metal ions, reactive oxygen species, and thiols.", Coordination Chemistry Reviews, 2012, 256(19-20), 2333-2356 (Special Issue on Metal Ions in Neurodegenerative Diseases [23440254], [doi[abs].

  28. Kielar, F; Helsel, ME; Wang, Q; Franz, KJ, "Prochelator BHAPI protects cells against paraquat-induced damage by ROS-triggered iron chelation.", MetallomicsAugust,, 2012, 4(9), 899-909 [22700084], [doi[abs].

  29. Rubino, JT; Franz, KJ, "Coordination chemistry of copper proteins: how nature handles a toxic cargo for essential function.", Journal of Inorganic Biochemistry, 2012, 107(1), 129-143 (invited contribution for an “Early Career Focused Review”.) [22204943], [doi[abs].

  30. Hyman, LM; Franz, KJ, "A Cell-Permeable Fluorescent Prochelator Responds to Hydrogen Peroxide and Metal Ions by Decreasing Fluorescence.", Inorganica Chimica Acta, 2012, 380, 125-134 (invited contribution for special issue: "Inorganic Chemistry - The Next Generation").) [22287796], [doi[abs].

  31. Franz, KJ, "Application of inorganic chemistry for non-cancer therapeutics", Dalton Transactions, 2012, 41(21), 6333-6334 ((guest editorial for themed issue).) [C2DT90061K], [doi].

  32. Leed, MGD; Wolkow, N; Pham, DM; Daniel, CL; Dunaief, JL; Franz, KJ, "Prochelators triggered by hydrogen peroxide provide hexadentate iron coordination to impede oxidative stress.", Journal of Inorganic BiochemistrySeptember,, 2011, 105(9), 1161-1172 ( [21708101], [doi[abs].

  33. Haas, KL; Putterman, AB; White, DR; Thiele, DJ; Franz, KJ, "Model peptides provide new insights into the role of histidine residues as potential ligands in human cellular copper acquisition via Ctr1.", Journal of the American Chemical SocietyMarch,, 2011, 133(12), 4427-4437 (doi: 10.1021/ja108890c.) [21375246], [doi[abs].

  34. Ciesienski, KL; Franz, KJ, "Keys for unlocking photolabile metal-containing cages.", Angewandte Chemie International EditionJanuary,, 2011, 50(4), 814-824 [21246677], [doi[abs].

  35. Rubino, JT; Chenkin, MP; Keller, M; Riggs-Gelasco, P; Franz, KJ, "A comparison of methionine, histidine and cysteine in copper(I)-binding peptides reveals differences relevant to copper uptake by organisms in diverse environments.", Metallomics, 2011, 3(1), 61-73 [21553704], [doi[abs].

  36. Ciesienski, KL; Haas, KL; Franz, KJ, "Development of next-generation photolabile copper cages with improved copper binding properties.", Dalton TransactionsOctober,, 2010, 39(40), 9538-9546 [20740238], [doi[abs].

  37. Rubino, JT; Riggs-Gelasco, P; Franz, KJ, "Methionine motifs of copper transport proteins provide general and flexible thioether-only binding sites for Cu(I) and Ag(I).", JBIC Journal of Biological Inorganic ChemistrySeptember,, 2010, 15(7), 1033-1049 [20437064], [doi[abs].

  38. Ciesienski, KL; Hyman, LM; Derisavifard, S; Franz, KJ, "Toward the detection of cellular copper(II) by a light-activated fluorescence increase.", Inorganic ChemistryAugust,, 2010, 49(15), 6808-6810 [20590142], [doi].

  39. Folk, DS; Franz, KJ, "A prochelator activated by beta-secretase inhibits Abeta aggregation and suppresses copper-induced reactive oxygen species formation.", Journal of the American Chemical SocietyApril,, 2010, 132(14), 4994-4995 [20297791], [doi[abs].

  40. Perez, LR; Franz, KJ, "Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease.", Dalton Transactions, 2010, 39(9), 2177-2187 [20162187], [doi[abs].

  41. Hyman, LM; Stephenson, CJ; Dickens, MG; Shimizu, KD; Franz, KJ, "Toward the development of prochelators as fluorescent probes of copper-mediated oxidative stress.", Dalton TransactionsJanuary,, 2010, 10.1039/b914568k(2), 568-576 [20023995], [doi[abs].

  42. Dickens, MG; Franz, KJ, "A prochelator activated by hydrogen peroxide prevents metal-induced amyloid Beta aggregation.", ChembiochemJanuary,, 2010, 11(1), 59-62 [19937900], [doi].

  43. Crider, SE; Holbrook, RJ; Franz, KJ, "Coordination of platinum therapeutic agents to met-rich motifs of human copper transport protein1.", Metallomics, 2010, 2(1), 74-83 (doi:10.1039/b916899k.) [21072377], [doi[abs].

  44. Tangen, E; Conradie, J; Franz, K; Friedle, S; Telser, J; Lippard, SJ; Ghosh, A, "Electronic structure of a paramagnetic {MNO}6 complex: MnNO 5,5-tropocoronand", Inorganic Chemistry, 2010, 49(6), 2701-2705 [doi[abs].

  45. Ciesienski, KL; Hyman, LM; Yang, DT; Haas, KL; Dickens, MG; Holbrook, RJ; Franz, KJ, "A photo-caged platinum(II) complex that increases cytotoxicity upon light activation", European Journal of Inorganic Chemistry, 2010(15), 2224-2228 [doi[abs].

  46. Franz, KJ; He, C, "The highways and byways of bioinorganic chemistry", Current Opinion in Chemical Biology, 2010, 14(2), 208-210 [doi].

  47. Haas, KL; Franz, KJ, "Application of metal coordination chemistry to explore and manipulate cell biology.", Chemical ReviewsOctober,, 2009, 109(10), 4921-4960 [19715312], [doi].

  48. Palmer, AE; Franz, KJ, "Introduction to cellular metal homeostasis and trafficking", Chemical Reviews, 2009, 109(10), 4533-4535 [doi].

  49. Charkoudian, LK; Dentchev, T; Lukinova, N; Wolkow, N; Dunaief, JL; Franz, KJ, "Iron prochelator BSIH protects retinal pigment epithelial cells against cell death induced by hydrogen peroxide.", Journal of Inorganic BiochemistryDecember,, 2008, 102(12), 2130-2135 (Young Investigator Special Issue on “Inorganic Biochemistry - The Next Generation”.) [18835041], [doi[abs].

  50. Ciesienski, KL; Haas, KL; Dickens, MG; Tesema, YT; Franz, KJ, "A photolabile ligand for light-activated release of caged copper.", Journal of the American Chemical SocietySeptember,, 2008, 130(37), 12246-12247 [18714999], [doi[abs].

  51. Tesema, YT; Pham, DM; Franz, KJ, "Counterions influence reactivity of metal ions with cysteinyldopa model compounds.", Inorganic ChemistryFebruary,, 2008, 47(3), 1087-1095 [18163613], [doi[abs].

  52. Franz, KJ, "Copper shares a piece of the π", Nature Chemical Biology, 2008, 4(2), 85-86 [nchembio0208-85], [doi[abs].

  53. Charkoudian, LK; Pham, DM; Kwon, AM; Vangeloff, AD; Franz, KJ, "Modifications of boronic ester pro-chelators triggered by hydrogen peroxide tune reactivity to inhibit metal-promoted oxidative stress.", Dalton TransactionsNovember,, 2007, 43(43), 5031-5042 [17992288], [doi[abs].

  54. Liu, LL; Franz, KJ, "Phosphorylation-dependent metal binding by alpha-synuclein peptide fragments.", JBIC Journal of Biological Inorganic Chemistry, 2007, 12(2), 234-247 [17082919], [doi[abs].

  55. Charkoudian, LK; Pham, DM; Franz, KJ, "A pro-chelator triggered by hydrogen peroxide inhibits iron-promoted hydroxyl radical formation.", Journal of the American Chemical SocietySeptember,, 2006, 128(38), 12424-12425 [16984186], [doi[abs].

  56. Tesema, YT; Pham, DM; Franz, KJ, "Synthesis and characterization of copper(II) complexes of cysteinyldopa and benzothiazine model ligands related to pheomelanin.", Inorganic ChemistryAugust,, 2006, 45(16), 6102-6104 [16878910], [doi[abs].

  57. Charkoudian, LK; Franz, KJ, "Fe(III)-coordination properties of neuromelanin components: 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid.", Inorganic ChemistryMay,, 2006, 45(9), 3657-3664 [16634598], [doi[abs].

  58. Jiang, J; Nadas, IA; Kim, MA; Franz, KJ, "A Mets motif peptide found in copper transport proteins selectively binds Cu(I) with methionine-only coordination.", Inorganic ChemistryDecember,, 2005, 44(26), 9787-9794 [16363848], [doi[abs].

  59. Liu, LL; Franz, KJ, "Phosphorylation of an alpha-synuclein peptide fragment enhances metal binding.", Journal of the American Chemical SocietyJuly,, 2005, 127(27), 9662-9663 [15998051], [doi[abs].

  60. Nitz, M; Sherawat, M; Franz, KJ; Peisach, E; Allen, KN; Imperiali, B, "Structural origin of the high affinity of a chemically evolved lanthanide-binding peptide", Angewandte Chemie - International Edition, 2004, 43(28), 3682-3685 [doi[abs].

  61. Wöhnert, J; Franz, KJ; Nitz, M; Imperiali, B; Schwalbe, H, "Protein Alignment by a Coexpressed Lanthanide-Binding Tag for the Measurement of Residual Dipolar Couplings", Journal of the American Chemical Society, 2003, 125(44), 13338-13339 [doi[abs].

  62. Nitz, M; Franz, KJ; Maglathlin, RL; Imperiali, B, "A powerful combinatorial screen to identify high-affinity terbium(III)-binding peptides", ChemBioChem, 2003, 4(4), 272-276 [doi[abs].

  63. Franz, KJ; Nitz, M; Imperiali, B, "Lanthanide-binding tags as versatile protein coexpression probes", ChemBioChem, 2003, 4(4), 265-271 [doi[abs].

  64. Franz, KJ; Doerrer, LH; Spingler, B; Lippard, SJ, "Pentacoordinate cobalt(III) thiolate and nitrosyl tropocoronand compounds", Inorganic Chemistry, 2001, 40(15), 3774-3780 [doi[abs].

  65. Franz, KJ; Lippard, SJ, "Nitrosyl transfer from manganese to iron in tropocoronand complexes", Inorganic Chemistry, 2000, 39(16), 3722-3723 [doi[abs].

  66. Franz, KJ; Singh, N; Spingler, B; Lippard, SJ, "Aminotroponiminates as ligands for potential metal-based nitric oxide sensors", Inorganic Chemistry, 2000, 39(18), 4081-4092 [doi[abs].

  67. Franz, KJ; Singh, N; Lippard, SJ, "Metal-based NO sensing by selective ligand dissociation", Angewandte Chemie - International Edition, 2000, 39(12), 2120-2122 [doi[abs].

  68. Franz, KJ; Lippard, SJ, "NO disproportionation reactivity of Fe tropocoronand complexes", Journal of the American Chemical Society, 1999, 121(45), 10504-10512 [doi[abs].

  69. Loehlin, JH; Franz, KJ; Gist, L; Moore, RH, "Supramolecular Alcohol-Amine Crystals and Their Hydrogen-Bond Patterns", Acta Crystallographica Section B: Structural Science, 1998, 54(5), 695-704 [abs].

  70. Franz, KJ; Lippard, SJ, "Disproportionation of nitric oxide promoted by a Mn tropocoronand", Journal of the American Chemical Society, 1998, 120(35), 9034-9040 [doi[abs].

  71. Huang, S-P; Franz, KJ; Arnold, EH; Devenyi, J; Fish, RH, "Polymer pendant ligand chemistry-5. The selective and competitive removal of Ag+, Hg2+, Cu2+, Pb2+ and Cd2+ ions from aqueous solution utilizing a N-sulfonylethylenebis(dithiocarbamate) ligand anchored on macroporous polystyrene-divinylbenzene beads", Polyhedron, 1996, 15(23), 4241-4254 [doi[abs].

  72. Huang, S-P; Franz, KJ; Olmstead, MM; Fish, RH, "Synthetic and structural studies of a linear bis-catechol amide, N,N′-bis(2,3-dihydroxybenzoyl)-1,7-diazaheptane (5-LICAM), and its complexes with Ni2+ and Co2+: Utilization of a polymer-supported, sulfonated analog, 5-LICAMS, as a biomimetic ligand for divalent metal ion removal from aqueous solution", Inorganic Chemistry, 1995, 34(11), 2820-2825 [abs].

  73. Huang, S-P; Li, W; Franz, KJ; Albright, RL; Fish, RH, "Polymer pendant ligand chemistry. 3. A biomimetic approach to selective metal ion removal and recovery from aqueous solution with polymer-supported sulfonated catechol and linear catechol amide ligands", Inorganic Chemistry, 1995, 34(11), 2813-2819 [abs].

Chapter in Book

  1. Wang, Q; Franz, KJ, "Detection of Metal Ions, Anions and Small Molecules Using Metal Complexes", in Inorganic Chemical Biology: Principles, Techniques and ApplicationsJune,, 2014, 233-274 [doi[abs].

  2. Franz, K. J.; Wang, Q., "Detection of Metal Ions, Anions, Small Molecules and Biomolecules using Metal Complexes", in Inorganic Chemical Biology: Principles, Techniques and Applications, edited by Gasser, G., Ed. , 2014, John Wiley & Sons, Ltd: UK.