Publications of Katherine J. Franz

Papers Submitted

  1. Franks, A.; Peng, D.; Yang, W.; Franz, K. J., "Characterization of a photoswitching chelator with light-modulated geometric, electronic, and metal-binding properties.", Inorganic chemistryFebruary,, 2014, 53(3), 1397-1405 [doi[abs].

Journal Articles

  1. AT Franks, Q Wang and KJ Franz, "A multifunctional, light-activated prochelator inhibits UVA-induced oxidative stress.", Bioorganic & medicinal chemistry lettersNovember,, 2015, 25(21), 4843-4847 [doi[abs].

  2. MJ Pushie, K Shaw, KJ Franz, J Shearer and KL Haas, "Model Peptide Studies Reveal a Mixed Histidine-Methionine Cu(I) Binding Site at the N-Terminus of Human Copper Transporter 1.", Inorganic chemistrySeptember,, 2015, 54(17), 8544-8551 [doi[abs].

  3. AL Crumbliss, KJ Franz and DJ Thiele, "Preface", BioMetalsJune,, 2015, 28(3), 431-431 [doi].

  4. ME Helsel and KJ Franz, "Pharmacological activity of metal binding agents that alter copper bioavailability.", Dalton transactions (Cambridge, England : 2003)May,, 2015, 44(19), 8760-8770 [doi[abs].

  5. J Bureš, H Jansová, J Stariat, T Filipský, P Mladěnka, T Šimůnek, R Kučera, J Klimeš, Q Wang, KJ Franz and P Kovaříková, "LC-UV/MS methods for the analysis of prochelator-boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) and its active chelator salicylaldehyde isonicotinoyl hydrazone (SIH).", Journal of pharmaceutical and biomedical analysisFebruary,, 2015, 105, 55-63 [doi[abs].

  6. B Alies, JD Wiener and KJ Franz, "A prochelator peptide designed to use heterometallic cooperativity to enhance metal ion affinity", Chem. Sci., 2015, 6(6), 3606-3610 [doi].

  7. Safi, R.; Nelson, E. R.; Chitneni, S. K.; Franz, K. J.; George, D. J.; Zalutsky, M. R.; McDonnell, D. P., "Copper signaling axis as a target for prostate cancer therapeutics.", Cancer research, 2014, 74(20), 5819-5831 [doi[abs].

  8. AT Franks and KJ Franz, "A prochelator with a modular masking group featuring hydrogen peroxide activation with concurrent fluorescent reporting.", Chemical communications (Cambridge, England)October,, 2014, 50(77), 11317-11320 [doi[abs].

  9. H Jansová, M Macháček, Q Wang, P Hašková, A Jirkovská, E Potůčková, F Kielar, KJ Franz and T Simůnek, "Comparison of various iron chelators and prochelators as protective agents against cardiomyocyte oxidative injury.", Free radical biology & medicineSeptember,, 2014, 74, 210-221 [doi[abs].

  10. RA Festa, ME Helsel, KJ Franz and DJ Thiele, "Exploiting innate immune cell activation of a copper-dependent antimicrobial agent during infection.", Chemistry & biologyAugust,, 2014, 21(8), 977-987 [doi[abs].

  11. DS Folk, F Kielar and KJ Franz, "Bioinorganic Neurochemistry"August,, 2013, 3, 207-240 [doi[abs].

  12. Franz, Katherine J., "Clawing back: broadening the notion of metal chelators in medicine.", Curr Opin Chem BiolApril,, 2013, 17(2), 143-149 [23332666], [doi[abs].

  13. Kumbhar, Anupa A. and Franks, Andrew T. and Butcher, Raymond J. and Franz, Katherine J., "Light uncages a copper complex to induce nonapoptotic cell death.", Chem Commun (Camb)March,, 2013, 49(24), 2460-2462, The Royal Society of Chemistry [23417227], [doi[abs].

  14. Kielar, F.; Wang, Q.; Boyle, P. D. and Franz, K. J., "A boronate prochelator built on a triazole framework for peroxide-triggered tridentate metal binding.", Inorganica Chim ActaDecember,, 2012, 3930, 294-303 [23439614], [doi[abs].

  15. Folk, Drew S. and Torosian, Justin C. and Hwang, Sunhee and McCafferty, Dewey G. and Franz, Katherine J., "Monitoring β-secretase activity in living cells with a membrane-anchored FRET probe.", Angew Chem Int Ed EnglOctober,, 2012, 51(43), 10795-10799 [23023944], [doi].

  16. Hyman, L. M. and Franz, K. J., "Probing oxidative stress: Small molecule fluorescent sensors of metal ions, reactive oxygen species, and thiols.", Coord Chem Rev, 2012, 256(19-20), 2333-2356 (Special Issue on Metal Ions in Neurodegenerative Diseases [23440254], [doi[abs].

  17. Kielar, F. and Helsel, M. E. and Wang, Q. and Franz, K. J., "Prochelator BHAPI protects cells against paraquat-induced damage by ROS-triggered iron chelation.", MetallomicsAugust,, 2012, 4(9), 899-909 [22700084], [doi[abs].

  18. Rubino, J. and Franz, K. J., "Coordination chemistry of copper proteins: how nature handles a toxic cargo for essential function.", J Inorg Biochem, 2012, 107(1), 129-143 (invited contribution for an “Early Career Focused Review”.) [22204943], [doi[abs].

  19. Hyman, L. M. and Franz, K. J., "A Cell-Permeable Fluorescent Prochelator Responds to Hydrogen Peroxide and Metal Ions by Decreasing Fluorescence.", Inorganica Chim Acta, 2012, 380, 125-134 (invited contribution for special issue: "Inorganic Chemistry - The Next Generation").) [22287796], [doi[abs].

  20. Franz, Katherine J., "Application of inorganic chemistry for non-cancer therapeutics", Dalton Transactions, 2012, 41(21), 6333-6334 ((guest editorial for themed issue).) [C2DT90061K], [doi].

  21. Leed, M. G. D.; Wolkow, N.; Pham, D. M.; Daniel, C. L.; Dunaief, J. L.; Franz, K. J., "Prochelators triggered by hydrogen peroxide provide hexadentate iron coordination to impede oxidative stress.", J Inorg BiochemSeptember,, 2011, 105(9), 1161-1172 ( [21708101], [doi[abs].

  22. Kathryn L. Haas, Allison B. Putterman, Daniel R. White, Dennis J. Thiele, and Katherine J. Franz, "Model peptides provide new insights into the role of histidine residues as potential ligands in human cellular copper acquisition via Ctr1.", J Am Chem SocMarch,, 2011, 133(12), 4427-4437 (doi: 10.1021/ja108890c.) [21375246], [doi[abs].

  23. Ciesienski, K. L. and Franz, K. J., "Keys for unlocking photolabile metal-containing cages.", Angew Chem Int Ed EnglJanuary,, 2011, 50(4), 814-824 [21246677], [doi[abs].

  24. Rubino, JT; Chenkin, MP; Keller, M; Riggs-Gelasco, P.; Franz, K. J., "A comparison of methionine, histidine and cysteine in copper(I)-binding peptides reveals differences relevant to copper uptake by organisms in diverse environments.", Metallomics, 2011, 3(1), 61-73 [21553704], [doi[abs].

  25. Ciesienski, K. L.; Haas, K. L.; Franz, K. J., "Development of next-generation photolabile copper cages with improved copper binding properties.", Dalton TransOctober,, 2010, 39(40), 9538-9546 [20740238], [doi[abs].

  26. Jeffrey T. Rubino, Pamela Riggs-Gelasco and Katherine J. Franz, "Methionine motifs of copper transport proteins provide general and flexible thioether-only binding sites for Cu(I) and Ag(I).", J Biol Inorg ChemSeptember,, 2010, 15(7), 1033-1049 [20437064], [doi[abs].

  27. Katie L. Ciesienski, Lynne M. Hyman, Samir Derisavifard and Katherine J. Franz, "Toward the detection of cellular copper(II) by a light-activated fluorescence increase.", Inorg ChemAugust,, 2010, 49(15), 6808-6810 [20590142], [doi].

  28. D.S. Folk and K.J. Franz, "A prochelator activated by beta-secretase inhibits Abeta aggregation and suppresses copper-induced reactive oxygen species formation.", J Am Chem SocApril,, 2010, 132(14), 4994-4995 [20297791], [doi[abs].

  29. L.R. Perez and K.J. Franz, "Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease.", Dalton Trans, 2010, 39(9), 2177-2187 [20162187], [doi[abs].

  30. L.M. Hyman, CJ. Stephenson, M.G. Dickens, K.D. Shimizu and K.J. Franz, "Toward the development of prochelators as fluorescent probes of copper-mediated oxidative stress.", Dalton TransJanuary,, 2010, 10.1039/b914568k(2), 568-576 [20023995], [doi[abs].

  31. M.G. Dickens and K.J. Franz, "A prochelator activated by hydrogen peroxide prevents metal-induced amyloid Beta aggregation.", ChembiochemJanuary,, 2010, 11(1), 59-62 [19937900], [doi].

  32. S.E. Crider, R. J. Holbrook and K.J. Franz, "Coordination of platinum therapeutic agents to met-rich motifs of human copper transport protein1.", Metallomics, 2010, 2(1), 74-83 (doi:10.1039/b916899k.) [21072377], [doi[abs].

  33. E Tangen, J Conradie, K Franz, S Friedle, J Telser, SJ Lippard and A Ghosh, "Electronic structure of a paramagnetic {MNO}6 complex: MnNO 5,5-tropocoronand", Inorganic Chemistry, 2010, 49(6), 2701-2705 [doi[abs].

  34. Katie L. Ciesienski, Lynne M. Hyman, Daniel T. Yang, Kathryn L. Haas, Marina G. Dickens, Robert J. Holbrook, Katherine J. Franz, "A photo-caged platinum(II) complex that increases cytotoxicity upon light activation", European Journal of Inorganic Chemistry, 2010(15), 2224-2228 [doi[abs].

  35. K.J. Franz and C. He, "The highways and byways of bioinorganic chemistry", Current Opinion in Chemical Biology, 2010, 14(2), 208-210 [doi].

  36. K.L. Haas and K.J. Franz, "Application of metal coordination chemistry to explore and manipulate cell biology.", Chem RevOctober,, 2009, 109(10), 4921-4960 [19715312], [doi].

  37. AE Palmer and KJ Franz, "Introduction to cellular metal homeostasis and trafficking", Chemical Reviews, 2009, 109(10), 4533-4535 [doi].

  38. Louise K. Charkoudian, Tzvete Dentchev, Nina Lukinova, Natalie Wolkow, Joshua L. Dunaief and Katherine J. Franz, "Iron prochelator BSIH protects retinal pigment epithelial cells against cell death induced by hydrogen peroxide.", J Inorg BiochemDecember,, 2008, 102(12), 2130-2135 (Young Investigator Special Issue on “Inorganic Biochemistry - The Next Generation”.) [18835041], [doi[abs].

  39. Katie L. Ciesienski, Kathryn L. Haas, Marina G. Dickens, Yohannes T. Tesema, and Katherine J. Franz, "A photolabile ligand for light-activated release of caged copper.", J Am Chem SocSeptember,, 2008, 130(37), 12246-12247 [18714999], [doi[abs].

  40. Yohannes T. Tesema, David M. Pham, and Katherine J. Franz, "Counterions influence reactivity of metal ions with cysteinyldopa model compounds.", Inorg ChemFebruary,, 2008, 47(3), 1087-1095 [18163613], [doi[abs].

  41. K.J. Franz, "Copper shares a piece of the π", Nature Chemical Biology, 2008, 4(2), 85-86 [nchembio0208-85], [doi[abs].

  42. Charkoudian, L. K.; Pham, D. M.; Kwan, A.; Vangeloff, A.; Franz, K. J., "Modifications of boronic ester pro-chelators triggered by hydrogen peroxide tune reactivity to inhibit metal-promoted oxidative stress.", Dalton TransNovember,, 2007, 43(43), 5031-5042 [17992288], [doi[abs].

  43. Lucy L. Liu and Katherine J. Franz, "Phosphorylation-dependent metal binding by alpha-synuclein peptide fragments.", J Biol Inorg Chem, 2007, 12(2), 234-247 [17082919], [doi[abs].

  44. Charkoudian, L. K.; Pham, D. M.; and Franz, K. J., "A pro-chelator triggered by hydrogen peroxide inhibits iron-promoted hydroxyl radical formation.", J Am Chem SocSeptember,, 2006, 128(38), 12424-12425 [16984186], [doi[abs].

  45. Tesema, Y. T.; Pham, D. M. and Franz, K. J., "Synthesis and characterization of copper(II) complexes of cysteinyldopa and benzothiazine model ligands related to pheomelanin.", Inorg ChemAugust,, 2006, 45(16), 6102-6104 [16878910], [doi[abs].

  46. Charkoudian, L. K.; Franz, K. J., "Fe(III)-coordination properties of neuromelanin components: 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid.", Inorg ChemMay,, 2006, 45(9), 3657-3664 [16634598], [doi[abs].

  47. Jiang, J.; Nadas, I. A.; Kim, M. A.; and Franz, K. J., "A Mets motif peptide found in copper transport proteins selectively binds Cu(I) with methionine-only coordination.", Inorg ChemDecember,, 2005, 44(26), 9787-9794 [16363848], [doi[abs].

  48. Liu, L. L.; Franz, K. J., "Phosphorylation of an alpha-synuclein peptide fragment enhances metal binding.", J Am Chem SocJuly,, 2005, 127(27), 9662-9663 [15998051], [doi[abs].

  49. M Nitz, M Sherawat, KJ Franz, E Peisach, KN Allen and B Imperiali, "Structural origin of the high affinity of a chemically evolved lanthanide-binding peptide", Angewandte Chemie - International Edition, 2004, 43(28), 3682-3685 [doi[abs].

  50. Wöhnert, J., Franz, K.J., Nitz, M., Imperiali, B., Schwalbe,H., "Protein Alignment by a Coexpressed Lanthanide-Binding Tag for the Measurement of Residual Dipolar Couplings", Journal of the American Chemical Society, 2003, 125(44), 13338-13339 [doi[abs].

  51. Nitz, M., Franz, K.J., Maglathlin, R., Imperiali, B., "A powerful combinatorial screen to identify high-affinity terbium(III)-binding peptides", ChemBioChem, 2003, 4(4), 272-276 [doi[abs].

  52. Franz, K.J., Nitz, M., Imperiali, B., "Lanthanide-binding tags as versatile protein coexpression probes", ChemBioChem, 2003, 4(4), 265-271 [doi[abs].

  53. Franz, K.J., Doerrer, L.H., Springler, B., Lippard, S.J., "Pentacoordinate cobalt(III) thiolate and nitrosyl tropocoronand compounds", Inorganic Chemistry, 2001, 40(15), 3774-3780 [doi[abs].

  54. Franz, K.J. and Lippard, S.J., "Nitrosyl transfer from manganese to iron in tropocoronand complexes", Inorganic Chemistry, 2000, 39(16), 3722-3723 [doi[abs].

  55. Franz, K.J., Singh, N., Spingler, B., Lippard, S.J., "Aminotroponiminates as ligands for potential metal-based nitric oxide sensors", Inorganic Chemistry, 2000, 39(18), 4081-4092 [doi[abs].

  56. Franz, K.J., Singh, N., Lippard, S.J., "Metal-based NO sensing by selective ligand dissociation", Angewandte Chemie - International Edition, 2000, 39(12), 2120-2122 [doi[abs].

  57. Franz, K.J. and Lippard, S.J., "NO disproportionation reactivity of Fe tropocoronand complexes", Journal of the American Chemical Society, 1999, 121(45), 10504-10512 [doi[abs].

  58. Loehlin, J.H., Franz, K.J., Gist, L., Moore, R.H., "Supramolecular Alcohol-Amine Crystals and Their Hydrogen-Bond Patterns", Acta Crystallographica Section B: Structural Science, 1998, 54(5), 695-704 [abs].

  59. Franz, K.J., and Lippard, S.J., "Disproportionation of nitric oxide promoted by a Mn tropocoronand", Journal of the American Chemical Society, 1998, 120(35), 9034-9040 [doi[abs].

  60. Huang, S.P., Franz, K.J., Arnold, E.H., Deveyi, J., Fish, R.H., "Polymer pendant ligand chemistry-5. The selective and competitive removal of Ag+, Hg2+, Cu2+, Pb2+ and Cd2+ ions from aqueous solution utilizing a N-sulfonylethylenebis(dithiocarbamate) ligand anchored on macroporous polystyrene-divinylbenzene beads", Polyhedron, 1996, 15(23), 4241-4254 [doi[abs].

  61. Huang, S.P., Franz, K.J., Olmstead, M.M., Fish, R.H., "Synthetic and structural studies of a linear bis-catechol amide, N,N′-bis(2,3-dihydroxybenzoyl)-1,7-diazaheptane (5-LICAM), and its complexes with Ni2+ and Co2+: Utilization of a polymer-supported, sulfonated analog, 5-LICAMS, as a biomimetic ligand for divalent metal ion removal from aqueous solution", Inorganic Chemistry, 1995, 34(11), 2820-2825 [abs].

  62. Huang, S.P., Li, W., Franz, K.J., Albright, R.L., "Polymer pendant ligand chemistry. 3. A biomimetic approach to selective metal ion removal and recovery from aqueous solution with polymer-supported sulfonated catechol and linear catechol amide ligands", Inorganic Chemistry, 1995, 34(11), 2813-2819 [abs].

Chapter in Book

  1. Q Wang and KJ Franz, "Detection of Metal Ions, Anions and Small Molecules Using Metal Complexes"June,, 2014, 233-274 [doi[abs].

  2. Franz, K. J.; Wang, Q., "Detection of Metal Ions, Anions, Small Molecules and Biomolecules using Metal Complexes", in Inorganic Chemical Biology: Principles, Techniques and Applications, edited by Gasser, G., Ed. , 2014, John Wiley & Sons, Ltd: UK.