Publications of Katherine J. Franz

Papers Submitted

  1. AT Franks, D Peng, W Yang and KJ Franz, "Characterization of a photoswitching chelator with light-modulated geometric, electronic, and metal-binding properties.", Inorganic chemistryFebruary,, 2014, 53(3), 1397-1405 [doi[abs].

Journal Articles

  1. AT Franks, Q Wang and KJ Franz, "A multifunctional, light-activated prochelator inhibits UVA-induced oxidative stress.", Bioorganic & medicinal chemistry lettersNovember,, 2015, 25(21), 4843-4847 [doi[abs].

  2. MJ Pushie, K Shaw, KJ Franz, J Shearer and KL Haas, "Model Peptide Studies Reveal a Mixed Histidine-Methionine Cu(I) Binding Site at the N-Terminus of Human Copper Transporter 1.", Inorganic chemistrySeptember,, 2015, 54(17), 8544-8551 [doi[abs].

  3. AL Crumbliss, KJ Franz and DJ Thiele, "Preface", BioMetalsJune,, 2015, 28(3), 431-431 [doi].

  4. ME Helsel and KJ Franz, "Pharmacological activity of metal binding agents that alter copper bioavailability.", Dalton transactions (Cambridge, England : 2003)May,, 2015, 44(19), 8760-8770 [doi[abs].

  5. J Bureš, H Jansová, J Stariat, T Filipský, P Mladěnka, T Šimůnek, R Kučera, J Klimeš, Q Wang, KJ Franz and P Kovaříková, "LC-UV/MS methods for the analysis of prochelator-boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) and its active chelator salicylaldehyde isonicotinoyl hydrazone (SIH).", Journal of pharmaceutical and biomedical analysisFebruary,, 2015, 105, 55-63 [doi[abs].

  6. B Alies, JD Wiener and KJ Franz, "A prochelator peptide designed to use heterometallic cooperativity to enhance metal ion affinity", Chem. Sci., 2015, 6(6), 3606-3610 [doi].

  7. R Safi, ER Nelson, SK Chitneni, KJ Franz, DJ George, MR Zalutsky and DP McDonnell, "Copper signaling axis as a target for prostate cancer therapeutics.", Cancer research, 2014, 74(20), 5819-5831 [repository], [doi[abs].

  8. AT Franks and KJ Franz, "A prochelator with a modular masking group featuring hydrogen peroxide activation with concurrent fluorescent reporting.", Chemical communications (Cambridge, England)October,, 2014, 50(77), 11317-11320 [doi[abs].

  9. H Jansová, M Macháček, Q Wang, P Hašková, A Jirkovská, E Potůčková, F Kielar, KJ Franz and T Simůnek, "Comparison of various iron chelators and prochelators as protective agents against cardiomyocyte oxidative injury.", Free radical biology & medicineSeptember,, 2014, 74, 210-221 [doi[abs].

  10. RA Festa, ME Helsel, KJ Franz and DJ Thiele, "Exploiting innate immune cell activation of a copper-dependent antimicrobial agent during infection.", Chemistry & biologyAugust,, 2014, 21(8), 977-987 [doi[abs].

  11. DS Folk, F Kielar and KJ Franz, "Bioinorganic Neurochemistry", scopusAugust,, 2013, 3, 207-240 [doi[abs].

  12. KJ Franz, "Clawing back: broadening the notion of metal chelators in medicine.", Curr Opin Chem BiolApril,, 2013, 17(2), 143-149 [23332666], [doi[abs].

  13. AA Kumbhar, AT Franks, RJ Butcher and KJ Franz, "Light uncages a copper complex to induce nonapoptotic cell death.", Chem Commun (Camb)March,, 2013, 49(24), 2460-2462, The Royal Society of Chemistry [23417227], [doi[abs].

  14. F Kielar, Q Wang, PD Boyle and KJ Franz, "A boronate prochelator built on a triazole framework for peroxide-triggered tridentate metal binding.", Inorganica Chim ActaDecember,, 2012, 3930, 294-303 [23439614], [doi[abs].

  15. DS Folk, JC Torosian, S Hwang, DG McCafferty and KJ Franz, "Monitoring β-secretase activity in living cells with a membrane-anchored FRET probe.", Angew Chem Int Ed EnglOctober,, 2012, 51(43), 10795-10799 [23023944], [doi].

  16. LM Hyman and KJ Franz, "Probing oxidative stress: Small molecule fluorescent sensors of metal ions, reactive oxygen species, and thiols.", Coord Chem Rev, 2012, 256(19-20), 2333-2356 (Special Issue on Metal Ions in Neurodegenerative Diseases [23440254], [doi[abs].

  17. F Kielar, ME Helsel, Q Wang and KJ Franz, "Prochelator BHAPI protects cells against paraquat-induced damage by ROS-triggered iron chelation.", MetallomicsAugust,, 2012, 4(9), 899-909 [22700084], [doi[abs].

  18. JT Rubino and KJ Franz, "Coordination chemistry of copper proteins: how nature handles a toxic cargo for essential function.", J Inorg Biochem, 2012, 107(1), 129-143 (invited contribution for an “Early Career Focused Review”.) [22204943], [doi[abs].

  19. LM Hyman and KJ Franz, "A Cell-Permeable Fluorescent Prochelator Responds to Hydrogen Peroxide and Metal Ions by Decreasing Fluorescence.", Inorganica Chim Acta, 2012, 380, 125-134 (invited contribution for special issue: "Inorganic Chemistry - The Next Generation").) [22287796], [doi[abs].

  20. KJ Franz, "Application of inorganic chemistry for non-cancer therapeutics", Dalton Transactions, 2012, 41(21), 6333-6334 ((guest editorial for themed issue).) [C2DT90061K], [doi].

  21. MG Leed, N Wolkow, DM Pham, CL Daniel, JL Dunaief and KJ Franz, "Prochelators triggered by hydrogen peroxide provide hexadentate iron coordination to impede oxidative stress.", J Inorg BiochemSeptember,, 2011, 105(9), 1161-1172 ( [21708101], [doi[abs].

  22. KL Haas, AB Putterman, DR White, DJ Thiele and KJ Franz, "Model peptides provide new insights into the role of histidine residues as potential ligands in human cellular copper acquisition via Ctr1.", J Am Chem SocMarch,, 2011, 133(12), 4427-4437 (doi: 10.1021/ja108890c.) [21375246], [doi[abs].

  23. KL Ciesienski and KJ Franz, "Keys for unlocking photolabile metal-containing cages.", Angew Chem Int Ed EnglJanuary,, 2011, 50(4), 814-824 [21246677], [doi[abs].

  24. JT Rubino, MP Chenkin, M Keller, P Riggs-Gelasco and KJ Franz, "A comparison of methionine, histidine and cysteine in copper(I)-binding peptides reveals differences relevant to copper uptake by organisms in diverse environments.", Metallomics, 2011, 3(1), 61-73 [21553704], [doi[abs].

  25. KL Ciesienski, KL Haas and KJ Franz, "Development of next-generation photolabile copper cages with improved copper binding properties.", Dalton TransOctober,, 2010, 39(40), 9538-9546 [20740238], [doi[abs].

  26. JT Rubino, P Riggs-Gelasco and KJ Franz, "Methionine motifs of copper transport proteins provide general and flexible thioether-only binding sites for Cu(I) and Ag(I).", J Biol Inorg ChemSeptember,, 2010, 15(7), 1033-1049 [20437064], [doi[abs].

  27. KL Ciesienski, LM Hyman, S Derisavifard and KJ Franz, "Toward the detection of cellular copper(II) by a light-activated fluorescence increase.", Inorg ChemAugust,, 2010, 49(15), 6808-6810 [20590142], [doi].

  28. DS Folk and KJ Franz, "A prochelator activated by beta-secretase inhibits Abeta aggregation and suppresses copper-induced reactive oxygen species formation.", J Am Chem SocApril,, 2010, 132(14), 4994-4995 [20297791], [doi[abs].

  29. LR Perez and KJ Franz, "Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease.", Dalton Trans, 2010, 39(9), 2177-2187 [20162187], [doi[abs].

  30. LM Hyman, CJ Stephenson, MG Dickens, KD Shimizu and KJ Franz, "Toward the development of prochelators as fluorescent probes of copper-mediated oxidative stress.", Dalton TransJanuary,, 2010, 10.1039/b914568k(2), 568-576 [20023995], [doi[abs].

  31. MG Dickens and KJ Franz, "A prochelator activated by hydrogen peroxide prevents metal-induced amyloid Beta aggregation.", ChembiochemJanuary,, 2010, 11(1), 59-62 [19937900], [doi].

  32. SE Crider, RJ Holbrook and KJ Franz, "Coordination of platinum therapeutic agents to met-rich motifs of human copper transport protein1.", Metallomics, 2010, 2(1), 74-83 (doi:10.1039/b916899k.) [21072377], [doi[abs].

  33. E Tangen, J Conradie, K Franz, S Friedle, J Telser, SJ Lippard and A Ghosh, "Electronic structure of a paramagnetic {MNO}6 complex: MnNO 5,5-tropocoronand", Inorganic Chemistry, 2010, 49(6), 2701-2705 [doi[abs].

  34. KL Ciesienski, LM Hyman, DT Yang, KL Haas, MG Dickens, RJ Holbrook and KJ Franz, "A photo-caged platinum(II) complex that increases cytotoxicity upon light activation", European Journal of Inorganic Chemistry, 2010(15), 2224-2228 [doi[abs].

  35. KJ Franz and C He, "The highways and byways of bioinorganic chemistry", Current Opinion in Chemical Biology, 2010, 14(2), 208-210 [doi].

  36. KL Haas and KJ Franz, "Application of metal coordination chemistry to explore and manipulate cell biology.", Chem RevOctober,, 2009, 109(10), 4921-4960 [19715312], [doi].

  37. AE Palmer and KJ Franz, "Introduction to cellular metal homeostasis and trafficking", Chemical Reviews, 2009, 109(10), 4533-4535 [doi].

  38. LK Charkoudian, T Dentchev, N Lukinova, N Wolkow, JL Dunaief and KJ Franz, "Iron prochelator BSIH protects retinal pigment epithelial cells against cell death induced by hydrogen peroxide.", J Inorg BiochemDecember,, 2008, 102(12), 2130-2135 (Young Investigator Special Issue on “Inorganic Biochemistry - The Next Generation”.) [18835041], [doi[abs].

  39. KL Ciesienski, KL Haas, MG Dickens, YT Tesema and KJ Franz, "A photolabile ligand for light-activated release of caged copper.", J Am Chem SocSeptember,, 2008, 130(37), 12246-12247 [18714999], [doi[abs].

  40. YT Tesema, DM Pham and KJ Franz, "Counterions influence reactivity of metal ions with cysteinyldopa model compounds.", Inorg ChemFebruary,, 2008, 47(3), 1087-1095 [18163613], [doi[abs].

  41. KJ Franz, "Copper shares a piece of the π", Nature Chemical Biology, 2008, 4(2), 85-86 [nchembio0208-85], [doi[abs].

  42. LK Charkoudian, DM Pham, AM Kwon, AD Vangeloff and KJ Franz, "Modifications of boronic ester pro-chelators triggered by hydrogen peroxide tune reactivity to inhibit metal-promoted oxidative stress.", Dalton TransNovember,, 2007, 43(43), 5031-5042 [17992288], [doi[abs].

  43. LL Liu and KJ Franz, "Phosphorylation-dependent metal binding by alpha-synuclein peptide fragments.", J Biol Inorg Chem, 2007, 12(2), 234-247 [17082919], [doi[abs].

  44. LK Charkoudian, DM Pham and KJ Franz, "A pro-chelator triggered by hydrogen peroxide inhibits iron-promoted hydroxyl radical formation.", J Am Chem SocSeptember,, 2006, 128(38), 12424-12425 [16984186], [doi[abs].

  45. YT Tesema, DM Pham and KJ Franz, "Synthesis and characterization of copper(II) complexes of cysteinyldopa and benzothiazine model ligands related to pheomelanin.", Inorg ChemAugust,, 2006, 45(16), 6102-6104 [16878910], [doi[abs].

  46. LK Charkoudian and KJ Franz, "Fe(III)-coordination properties of neuromelanin components: 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid.", Inorg ChemMay,, 2006, 45(9), 3657-3664 [16634598], [doi[abs].

  47. J Jiang, IA Nadas, MA Kim and KJ Franz, "A Mets motif peptide found in copper transport proteins selectively binds Cu(I) with methionine-only coordination.", Inorg ChemDecember,, 2005, 44(26), 9787-9794 [16363848], [doi[abs].

  48. LL Liu and KJ Franz, "Phosphorylation of an alpha-synuclein peptide fragment enhances metal binding.", J Am Chem SocJuly,, 2005, 127(27), 9662-9663 [15998051], [doi[abs].

  49. M Nitz, M Sherawat, KJ Franz, E Peisach, KN Allen and B Imperiali, "Structural origin of the high affinity of a chemically evolved lanthanide-binding peptide", Angewandte Chemie - International Edition, 2004, 43(28), 3682-3685 [doi[abs].

  50. J Wöhnert, KJ Franz, M Nitz, B Imperiali and H Schwalbe, "Protein Alignment by a Coexpressed Lanthanide-Binding Tag for the Measurement of Residual Dipolar Couplings", Journal of the American Chemical Society, 2003, 125(44), 13338-13339 [doi[abs].

  51. M Nitz, KJ Franz, RL Maglathlin and B Imperiali, "A powerful combinatorial screen to identify high-affinity terbium(III)-binding peptides", ChemBioChem, 2003, 4(4), 272-276 [doi[abs].

  52. KJ Franz, M Nitz and B Imperiali, "Lanthanide-binding tags as versatile protein coexpression probes", ChemBioChem, 2003, 4(4), 265-271 [doi[abs].

  53. KJ Franz, LH Doerrer, B Spingler and SJ Lippard, "Pentacoordinate cobalt(III) thiolate and nitrosyl tropocoronand compounds", Inorganic Chemistry, 2001, 40(15), 3774-3780 [doi[abs].

  54. KJ Franz and SJ Lippard, "Nitrosyl transfer from manganese to iron in tropocoronand complexes", Inorganic Chemistry, 2000, 39(16), 3722-3723 [doi[abs].

  55. KJ Franz, N Singh, B Spingler and SJ Lippard, "Aminotroponiminates as ligands for potential metal-based nitric oxide sensors", Inorganic Chemistry, 2000, 39(18), 4081-4092 [doi[abs].

  56. KJ Franz, N Singh and SJ Lippard, "Metal-based NO sensing by selective ligand dissociation", Angewandte Chemie - International Edition, 2000, 39(12), 2120-2122 [doi[abs].

  57. KJ Franz and SJ Lippard, "NO disproportionation reactivity of Fe tropocoronand complexes", Journal of the American Chemical Society, 1999, 121(45), 10504-10512 [doi[abs].

  58. JH Loehlin, KJ Franz, L Gist and RH Moore, "Supramolecular Alcohol-Amine Crystals and Their Hydrogen-Bond Patterns", Acta Crystallographica Section B: Structural Science, 1998, 54(5), 695-704 [abs].

  59. KJ Franz and SJ Lippard, "Disproportionation of nitric oxide promoted by a Mn tropocoronand", Journal of the American Chemical Society, 1998, 120(35), 9034-9040 [doi[abs].

  60. S-P Huang, KJ Franz, EH Arnold, J Devenyi and RH Fish, "Polymer pendant ligand chemistry-5. The selective and competitive removal of Ag+, Hg2+, Cu2+, Pb2+ and Cd2+ ions from aqueous solution utilizing a N-sulfonylethylenebis(dithiocarbamate) ligand anchored on macroporous polystyrene-divinylbenzene beads", Polyhedron, 1996, 15(23), 4241-4254 [doi[abs].

  61. SP Huang, KJ Franz, MM Olmstead and RH Fish, "Synthetic and structural studies of a linear bis-catechol amide, N,N′-bis(2,3-dihydroxybenzoyl)-1,7-diazaheptane (5-LICAM), and its complexes with Ni2+ and Co2+: Utilization of a polymer-supported, sulfonated analog, 5-LICAMS, as a biomimetic ligand for divalent metal ion removal from aqueous solution", Inorganic Chemistry, 1995, 34(11), 2820-2825 [abs].

  62. S-P Huang, W Li, KJ Franz, RL Albright and RH Fish, "Polymer pendant ligand chemistry. 3. A biomimetic approach to selective metal ion removal and recovery from aqueous solution with polymer-supported sulfonated catechol and linear catechol amide ligands", Inorganic Chemistry, 1995, 34(11), 2813-2819 [abs].

Chapter in Book

  1. Q Wang and KJ Franz, "Detection of Metal Ions, Anions and Small Molecules Using Metal Complexes", in Inorganic Chemical Biology: Principles, Techniques and Applications, scopusJune,, 2014, 233-274 [doi[abs].

  2. Franz, K. J.; Wang, Q., "Detection of Metal Ions, Anions, Small Molecules and Biomolecules using Metal Complexes", in Inorganic Chemical Biology: Principles, Techniques and Applications, edited by Gasser, G., Ed. , 2014, John Wiley & Sons, Ltd: UK.