Publications of Katherine J Franz

Papers Submitted

  1. Safi, R.; Nelson, E.R.; Chitneni, S.K.; Franz, K.J.; Thiele, D.J.; George, D.J.; Zalutsky, M.R.; McDonnell, D.P., "The Copper-Signaling Axis as a Target for Prostate Cancer Therapeutics", Cancer Research, 2013.

  2. Franks, A.; Peng, D.; Yang, W.; Franz, K. J., "Characterization of a photoswitching chelator with light-modulated geometric, electronic and metal-binding properties", Inorg. Chem, 2013.

Journal Articles

  1. Franz, Katherine J., "Clawing back: broadening the notion of metal chelators in medicine", Current Opinion in Chemical Biology, 20130 [S1367593112001652], [doi].

  2. Kumbhar, Anupa A. and Franks, Andrew T. and Butcher, Raymond J. and Franz, Katherine J., "Light uncages a copper complex to induce nonapoptotic cell death", Chemical Communications, 2013, 2460--2462, The Royal Society of Chemistry [C3CC38927H[abs].

  3. Kielar, F. and Helsel, M. E. and Wang, Q. and Franz, K. J., "Prochelator BHAPI protects cells against paraquat-induced damage by ROS-triggered iron chelation", MetallomicsJune,, 2012 [doi[abs].

  4. Franz, Katherine J., "Application of inorganic chemistry for non-cancer therapeutics", Dalton Transactions, 2012, 41(21), 6333--6334 ((guest editorial for themed issue).) [C2DT90061K].

  5. Kielar, F.; Wang, Q.; Boyle, P. D. and Franz, K. J., "A boronate prochelator built on a triazole framework for peroxide-triggered tridentate metal binding", Inorganica Chimica Acta, 20120 [S0020169312003714].

  6. Folk, Drew S. and Torosian, Justin C. and Hwang, Sunhee and McCafferty, Dewey G. and Franz, Katherine J., "Monitoring Beta-Secretase Activity in Living Cells with a Membrane-Anchored FRET Probe", Angewandte Chemie International Edition, 2012, in press [anie.201206673], [doi].

  7. Rubino, J. and Franz, K. J., "Coordination Chemistry of Copper Proteins: How Nature Handles a Toxic Cargo for Essential Function", J. Inorg. Biochem., 2012, 107, 129-143 (invited contribution for an “Early Career Focused Review”.) [doi].

  8. Hyman, L. M. and Franz, K. J., "A cell-permeable fluorescent prochelator responds to hydrogen peroxide and metal ions by decreasing fluorescence", Inorg. Chim. Acta, 2012, 380, 125-134 (invited contribution for special issue: "Inorganic Chemistry - The Next Generation").) [doi].

  9. Hyman, L. M. and Franz, K. J., "Probing Oxidative Stress: Small Molecule Fluorescent Sensors of Metal Ions, Reactive Oxygen Species, and Thiols", Coord. Chem. Rev., 2012 (Special Issue on Metal Ions in Neurodegenerative Diseases http://dx.doi.org/10.1016/j.ccr.2012.03.009.) [doi].

  10. Leed, M. G. D.; Wolkow, N.; Pham, D. M.; Daniel, C. L.; Dunaief, J. L.; Franz, K. J., "Prochelators triggered by hydrogen peroxide provide hexadentate iron coordination to impede oxidative stress", J. Inorg. Biochem., 2011, 105, 1161-1172 (http://dx.doi.org/10.1016/j.jinorgbio.2011.05.023.) [doi].

  11. Rubino, JT; Chenkin, MP; Keller, M; Riggs-Gelasco, P.; Franz, K. J., "A comparison of methionine, histidine and cysteine in copper(I)-binding peptides reveals differences relevant to copper uptake by organisms in diverse environments", Metallomics, 2011, 3(1), 61-73 [doi].

  12. Ciesienski, K. L. and Franz, K. J., "Keys for Unlocking Photolabile Metal-Containing Cages", Angew. Chem. Int. Ed. Eng., 2011, 50, 814–824 [doi].

  13. Kathryn L. Haas, Allison B. Putterman, Daniel R. White, Dennis J. Thiele, and Katherine J. Franz, "Model Peptides Provide New Insights into the Role of Histidine Residues as Potential Ligands in Human Cellular Copper Acquisition via Ctr1", J. Am. Chem. Soc., 2011 (doi: 10.1021/ja108890c.) [doi].

  14. Ciesienski, K. L.; Haas, K. L.; Franz, K. J., "Development of next-generation photolabile copper cages with improved copper binding properties", Dalton Trans., 2010 [C0DT00770F], [doi].

  15. Katie L. Ciesienski, Lynne M. Hyman, Samir Derisavifard and Katherine J. Franz, "Toward the Detection of Cellular Copper(II) by a Light-Activated Fluorescence Increase", Inorg. Chem., 2010 [ic1004165], [doi].

  16. S.E. Crider, R. J. Holbrook and K.J. Franz, "Coordination of platinum therapeutic agents to met-rich motifs of human copper transport protein1", Metallomics, 2010, 2, 74-83 (doi:10.1039/b916899k.) [article.asp], [doi].

  17. L.R. Perez and K.J. Franz, "Minding metals: Tailoring multifunctional chelating agents for neurodegenerative disease", Dalton Trans., 2010, 10.1039/b919237a [article.asp].

  18. Katie L. Ciesienski, Lynne M. Hyman, Daniel T. Yang, Kathryn L. Haas, Marina G. Dickens, Robert J. Holbrook, Katherine J. Franz, "A Caged Platinum(II) Complex that Increases Cytotoxicity upon Light Activation", Eur. J. Inorg. Chem., 2010, 10.1002/ejic.201000098 [doi].

  19. Jeffrey T. Rubino, Pamela Riggs-Gelasco and Katherine J. Franz, "Methionine motifs of copper transport proteins provide general and flexible thioether-only binding sites for Cu(I) and Ag(I)", J. Biol. Inorg. Chem., 2010, 10.1007/s00775-010-0663-9 [doi].

  20. D.S. Folk and K.J. Franz, "A Prochelator Activated by β-Secretase Inhibits Aβ Aggregation and Suppresses Copper-Induced Reactive Oxygen Species Formation", J. Am. Chem. Soc., 2010, 10.1021/ja100943r [doi].

  21. K.J. Franz and C. He, "The highways and byways of bioinorganic chemistry", Current Opinion in Chemical Biology, 2010, 10.1016/j.cbpa.2010.02.011 [doi].

  22. L.M. Hyman, CJ. Stephenson, M.G. Dickens, K.D. Shimizu and K.J. Franz, "Toward the development of prochelators as fluorescent probes of copper-mediated oxidative stress", Dalton Trans., 2009, 10.1039/b914568k [article.asp].

  23. M.G. Dickens and K.J. Franz, "A Prochelator Activated by Hydrogen Peroxide Prevents Metal-Induced Amyloid Beta Aggregation", ChemBioChem, 2009, 10.1002/cbic.200900597 [abstract].

  24. K.L. Haas and K.J. Franz, "Application of Metal Coordination Chemistry To Explore and Manipulate Cell Biology", Chem. Rev., 2009, Publication Date (Web): August 28, 2009 [cr900134a].

  25. Louise K. Charkoudian, Tzvete Dentchev, Nina Lukinova, Natalie Wolkow, Joshua L. Dunaief and Katherine J. Franz, "Iron Prochelator BSIH Protects Retinal Pigment Epithelial Cells against Cell Death Induced by Hydrogen Peroxide", J. Inorg. Biochem., 2008, 102, 2130–2135 (Young Investigator Special Issue on “Inorganic Biochemistry - The Next Generation”.) [001].

  26. Katie L. Ciesienski, Kathryn L. Haas, Marina G. Dickens, Yohannes T. Tesema, and Katherine J. Franz, "A Photolabile Ligand for Light-Activated Release of Caged Copper", J. Am. Chem. Soc., 2008, 130, 12246–12247 [ja8047442].

  27. Yohannes T. Tesema, David M. Pham, and Katherine J. Franz, "Counterions Influence Reactivity of Metal Ions with Cysteinyldopa Model Compounds", Inorg. Chem., 2008, 47(3), 1087 -1095 [ic701889w].

  28. K.J. Franz, "Copper Shares a Piece of the Pi", Nature Chem. Biol., 2008, 4(2), 85-6 [nchembio0208-85].

  29. Charkoudian, L. K.; Pham, D. M.; Kwan, A.; Vangeloff, A.; Franz, K. J., "Modifications of Boronic Ester Pro-chelators Triggered by Hydrogen Peroxide Tune Reactivity to Inhibit Metal-Promoted Oxidative Stress", Dalton Trans., 2007, 43, 5031–5042 [b705199a].

  30. Lucy L. Liu and Katherine J. Franz, "Phosphorylation-dependent metal binding by α-synuclein peptide fragments", J. Biol. Inorg. Chem., 2007, 12, 234–247 [available here].

  31. Charkoudian, L. K.; Pham, D. M.; and Franz, K. J., "A Pro-Chelator Triggered by Hydrogen Peroxide Inhibits Iron-Promoted Hydroxyl Radical Formation", J. Am. Chem. Soc., 2006, 128, 12424-12425 [ja064806w].

  32. Tesema, Y. T.; Pham, D. M. and Franz, K. J., "Synthesis and Characterization of Copper(II) Complexes of Cysteinyldopa and Benzothiazine Model Ligands Related to Pheomelanin", Inorg. Chem., 2006, 45, 6102 - 6104 [ic060262n].

  33. Charkoudian, L. K.; Franz, K. J., "Fe(III) Coordination Properties of Neuromelanin Components: 5,6-Dihydroxyindole and 5,6-Dihydroxyindole-2-carboxylic Acid", Inorg. Chem., 2006, 45(9), 3657 - 3664 [ic060014r].

  34. Jiang, J.; Nadas, I. A.; Kim, M. A.; and Franz, K. J., "A Mets Motif Peptide Found in Copper Transport Proteins Selectively Binds Cu(I) with Methionine-Only Coordination", Inorg. Chem., 2005, 44, 9787–9794 [ic051180m].

  35. Liu, L. L.; Franz, K. J., "Phosphorylation of an alpha-Synuclein Peptide Fragment Enhances Metal Binding", J. Am. Chem. Soc., 2005, 127, 9662–9663 [ja043247v].

  36. Franz, K.J., Nitz, M., Imperiali, B., "Lanthanide-Binding Tags as Versatile Protein Coexpression Probes", ChemBioChem, 2003, 4, 265-271.

  37. Nitz, M., Franz, K.J., Maglathlin, R., Imperiali, B., "A Powerful Combinatorial Screen to Identify High-Affinity Terbium(III)-Binding Peptides", ChemBioChem, 2003, 4, 272-276.

  38. Wöhnert, J., Franz, K.J., Nitz, M., Imperiali, B., Schwalbe,H., "Protein Alignment by a Coexpressed Lanthanide-Binding Tag for the Measurement of Residual Dipolar Couplings", J. Am. Chem. Soc., 2003, 125(44), 13338–13339.

  39. Franz, K.J., Doerrer, L.H., Springler, B., Lippard, S.J., "Pentacoordinate Cobalt(III) Thiolate and Nitrosyl Tropocoronand Compounds", Inorg. Chem., 2001, 40, 3774-3780.

  40. Franz, K.J., Singh, N., Lippard, S.J., "Metal-Based NO Sensing by Selective Ligand Dissociation", Angew. Chemie Int. Ed., 2000, 39, 2120-2121.

  41. Franz, K.J., Singh, N., Spingler, B., Lippard, S.J., "Aminotroponiminates as Ligands for Potential Metal-Based NO Sensors", Inorg. Chem., 2000, 39, 4081-4092.

  42. Franz, K.J. and Lippard, S.J., "Nitrosyl Transfer from Manganese to Iron in Tropocoronand Complexes", Inorg. Chem, 2000, 39, 3722-3733.

  43. Franz, K.J. and Lippard, S.J., "NO Disproportionation Reactivity of Fe Tropocoronand Complexes", J. Am. Chem. Soc., 1999, 121, 10504-10512.

  44. Franz, K.J., and Lippard, S.J., "Disproportionation of Nitric Oxide Promoted by a Mn Tropocoronand", J. Am. Chem. Soc., 1998, 120, 9034-9040.

  45. Loehlin, J.H., Franz, K.J., Gist, L., Moore, R.H., "Supramolecular Alcohol-Amine Crystals and their Hydrogen-Bond Patterns", Acra Cryst B, 1998, 54, 695-704.

  46. Huang, S.P., Franz, K.J., Arnold, E.H., Deveyi, J., Fish, R.H., "Polymer Pendant Ligand Chemistry. 5. The Selective and Competitive Removal of Ag+, Hg(2+, Cu2+, Pb2+ and Cd2+ Ions from Aqueous Solution Utilizing a N-Sufonylethylenebis(dithiocargamate) Ligand Anchored on Macroporous Polystyrene-divinylbenzene Beads", Polyhedron, 1996, 15, 4241-4254.

  47. Huang, S.P., Li, W., Franz, K.J., Albright, R.L., "Polymer Pendant Ligand Chemistry. 3. A Biominimetic Approach to Selective Metal Ion Removal and Recovery from Aqueous Solution with Polymer-Supported Sulfonated Catechol and Linear Catechol Amide Ligands", Inorg. Chem., 1995, 34, 2813-2819.

  48. Huang, S.P., Franz, K.J., Olmstead, M.M., Fish, R.H., "Synthetic and Structural Studies of a Linear Bis-Catechol Amide, N, N'-Bis (2,3-Dihydrorrybenzoyl)-1,7-Diazaheptane (5-Licam), and Its Complexes with Ni2+ and Co2+ - Utilization of a Polymer-Supported, Sulfonated Analog, 5-Licams, as a Biomimetic Ligand for Divalent Metal Ion Removal from Aqueous Solution", Inorg. Chem, 1995, 34, 2820-2825.

Chapter in Book

  1. Franz, K. J.; Wang, Q., "Detection of Metal Ions, Anions, Small Molecules and Biomolecules using Metal Complexes", in Inorganic Chemical Biology: Principles, Techniques and Applications, edited by Gasser, G., Ed. , 2014, John Wiley & Sons, Ltd: UK.